MSc Microbiology, Semester 1
Presentation on Topic: Allosteric Enzyme
M.Sc. Microbiology – Semester 1
Subject: Bioenzymes
Submitted to: Microbiology Department
Submitted by: Sakshi Jha
Introduction
Properties of Allosteric Enzymes
Kinetic Properties
Allosteric Effectors
Types of Allosteric Regulation
Definition of allosteric enzymes
General role in metabolism
Importance in regulation of biochemical pathways
Multi-subunit structure
Presence of active site & regulatory site
Conformational changes upon effector binding
Exhibit cooperative binding
Show sigmoidal (S-shaped) kinetics instead of hyperbolic curve
Positive & negative cooperativity
Role of substrate concentration
Activators: enhance enzyme activity
Inhibitors: reduce enzyme activity
Bind at regulatory (allosteric) sites
Positive Regulation (Activation)
Negative Regulation (Inhibition)
Homotropic effectors (substrate itself acts as effector)
Heterotropic effectors (different molecules act as effector)
Feedback inhibition in metabolic pathways
Example: ATCase inhibited by CTP
Importance in maintaining homeostasis
Drug design and therapeutic targets
Regulation of metabolic diseases
Industrial enzyme technology
Allosteric enzymes act as key regulatory proteins
Provide control over metabolic flux
Crucial in medical & industrial applications
Reference from local MSc book
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