Understanding DNA Repair Mechanisms
Pandit Shambhunath Shukla Vishwavidyalaya is dedicated to providing quality education and fostering intellectual growth in Shahdol.
Located in Shahdol, the university serves as a hub for higher learning in the region and promotes local development.
The college emphasizes academic excellence, research, and community engagement to prepare students for future success.
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Welcome to an educational journey into DNA repair. We are thrilled to begin exploring. Let's start now!
DNA is constantly exposed to damaging agents which ensures genetic information is accurately preserved.
DNA damage is caused by external sources such as radiation, chemicals, and internal metabolic processes which causes the risk.
DNA repair mechanisms are essential for maintaining genomic stability and preventing mutations which helps to secure from risk.
DNA repair pathways act as a cellular defense system by identifying and correcting DNA damage.
Effective DNA repair is crucial for preventing cancer, aging, and other diseases which is beneficial for human being.
Damaged or modified bases are removed by DNA glycosylases, followed by AP endonuclease and polymerase activity.
Bulky DNA lesions, such as thymine dimers, are removed through incision, excision, and repair synthesis and helps to cure.
Incorrectly paired bases are identified and corrected by MutS, MutL, and MutH proteins which makes it efficient.
Double-strand breaks are repaired using a homologous template, ensuring accurate restoration of genetic information which results good.
Broken DNA ends are directly ligated, often resulting in small insertions or deletions which leads to stability.
Defects in DNA repair pathways increase the risk of mutations, leading to cancer development and progression.
Accumulation of DNA damage contributes to cellular senescence and aging, affecting overall health and longevity.
DNA repair pathways are potential targets for cancer therapy, aiming to enhance the effectiveness of treatments.
Inherited mutations in DNA repair genes can cause genetic disorders, such as Xeroderma Pigmentosum and Fanconi Anemia.
Understanding individual variations in DNA repair capacity can inform personalized medicine approaches and improve patient outcomes.
We extend our sincere gratitude to Pandit Shambhunath Shukla Vishwavidyalaya, Shahdol.
Special thanks to the faculty and staff for their support in preparing this presentation.
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We hope this presentation has inspired you to continue learning about DNA repair and its importance.