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The Power of Tofacitinib in Dermatology

Exploring the Clinical Applications and Efficacy of a Novel Drug

Introduction

  • Tofacitinib is a novel drug used in dermatology
  • It is gaining popularity in Pakistan and has numerous clinical applications
  • Approved by FDA in 2012
  • Mechanism of action: Inhibitor of enzyme genus kinase
  • Blocks inflammatory effects of diseases

Medical Indications

  • FDA approved for rheumatoid arthritis in 2012
  • Also approved for ulcerative colitis and ankylosing spondylitis
  • Significant improvement observed in phase 3 trials for ulcerative colitis
  • Surprising approval for severe and critical COVID-19 patients

Tofacitinib in Dermatological Conditions

  • Promising treatment for psoriasis and psoriatic arthritis
  • Clinical trials show reasonable efficacy in both conditions
  • Effective topical treatment option for psoriasis
  • Potential application in alopecia areata and vitiligo
  • Improvement shown in atopic eczema

Safety Profile and Precautions

  • Relatively safe with low incidence of serious side effects
  • Common side effects include headache and diarrhea
  • Caution in specific populations like older adults and pregnant women
  • Thorough investigations required before prescribing tofacitinib
  • Potential risk of serious infections and other complications

Conclusion

  • Tofacitinib is a valuable addition to dermatology treatment in Pakistan
  • Well-tolerated with fewer side effects compared to other drugs
  • Effective in various dermatological conditions
  • Requires careful monitoring and investigations before prescription

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