Local Anesthesia Systemic Toxicity: From History to Practice
Understanding the risks, prevention, and management
Introduction
- Acknowledgement of the course organizers and presenters
- Welcome and introduction to the topic
- Overview of the speaker's credentials and expertise
- Brief outline of the presentation's objectives and key points
What is Local Anesthesia Systemic Toxicity?
- Definition and overview of local anesthesia systemic toxicity (LAST)
- Explanation of how local anesthesia can have systemic effects
- Importance of understanding LAST for medical professionals
- Highlighting the devastating consequences of LAST
Factors Influencing LAST
- Intrinsic factors: potency, solubility, metabolism
- Patient factors: age, sex, comorbidities
- Injection technique and site: vascularity, proximity to neural structures
- Role of pharmacogenetics in LAST
Mechanism of Local Anesthesia Action
- Overview of the mechanism of action of local anesthesia
- Differentiating between ester and amide local anesthetics
- Explanation of how local anesthesia blocks nerve transmission
- Interaction with sodium channels and other receptors
Prevention of LAST
- Role of proper dosage calculation and administration
- Importance of accurate localization and injection technique
- Benefits of ultrasound-guided nerve blocks
- Avoidance of high-risk situations and patient monitoring
Management of LAST
- Immediate actions in case of suspected LAST
- Airway management and oxygenation
- Use of lipid emulsion therapy (intralipid)
- Resuscitation guidelines specific to LAST
Case Studies and Statistics
- Reviewing case studies and statistics on LAST
- Highlighting the incidence and outcomes of LAST
- Comparing data from different regions and sources
- Discussing limitations and ongoing research
Conclusion
- Summarizing the key points and takeaways
- Highlighting the importance of LAST prevention and management
- Stressing the need for ongoing research and education
- Thanking the audience for their attention